Non-alcoholic Steatohepatitis Drug Market Insights 2025, Analysis and Forecast to 2030, by Manufacturers, Regions, Technology

By: HDIN Research Published: 2025-04-07 Pages: 104
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Non-alcoholic Steatohepatitis Drug Market Summary
Introduction
Non-alcoholic Steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease marked by liver inflammation and fibrosis, often linked to obesity and metabolic syndrome. Globally, NASH prevalence rose from 264 million in 2018 to 296 million in 2023, projected to reach 342 million by 2030. The NASH Drug market focuses on therapies to halt progression, reduce fat accumulation, and prevent cirrhosis, with resmetirom—approved by the FDA in March 2024 by Madrigal Pharmaceuticals—as the first drug for moderate-to-advanced NASH fibrosis. The industry is characterized by intense R&D, addressing a growing epidemic with significant unmet needs and a shift toward metabolic-targeted therapies.

Market Size and Growth Forecast
The global Non-alcoholic Steatohepatitis Drug market is estimated at USD 0.3 billion to USD 0.6 billion in 2025, with an extraordinary CAGR of 100% to 110% through 2030, potentially reaching USD 10 billion to USD 24 billion. This explosive growth reflects resmetirom’s approval and robust pipeline activity.

Regional Analysis
North America: Expected at 95% to 105%, the U.S. leads with high obesity rates and advanced healthcare. Trends focus on metabolic drugs and diagnostics.
Europe: Forecasted at 90% to 100%, Germany and France grow rapidly. Trends emphasize lifestyle-linked therapies.
Asia Pacific: Projected at 100% to 110%, China drives growth with rising prevalence. Trends highlight local R&D.
South Ameica: Anticipated at 85% to 95%, Brazil emerges. Trends favor affordable options.
Middle East and Africa: Expected at 80% to 90%, UAE leads. Trends focus on awareness and access.

Key Market Players
AstraZeneca PLC: A UK leader, AstraZeneca targets metabolic diseases like NASH.
Eli Lilly: A U.S. firm, Lilly advances NASH therapies with metabolic focus.
Gilead Sciences: A U.S. giant, Gilead explores liver disease solutions.
Merck & Co. Inc.: A U.S. player, Merck innovates in NASH treatments.
Novo Nordisk: A Danish company, Novo Nordisk leverages diabetes expertise for NASH.
Novartis AG: A Swiss firm, Novartis focuses on fibrosis therapies.
Pfizer Inc.: A U.S. leader, Pfizer targets metabolic liver conditions.
Roche Holding AG: A Swiss giant, Roche explores NASH innovations.
Enanta Pharmaceuticals Inc.: A U.S. biotech, Enanta develops liver-targeted drugs.
Ionis Pharmaceuticals Inc.: A U.S. entity, Ionis advances RNA therapies for NASH.
NGM Biopharmaceuticals Inc.: A U.S. firm, NGM targets metabolic pathways.
Pliant Therapeutics Inc.: A U.S. biotech, Pliant focuses on anti-fibrotic agents.
Terns Pharmaceuticals Inc.: A U.S. company, Terns innovates in NASH treatments.
89bio Inc.: A U.S. entity, 89bio develops metabolic therapies.

Porter’s Five Forces Analysis
●Threat of New Entrants: High, with blockbuster potential attracting biotechs despite R&D costs.
●Threat of Substitutes: Moderate, with lifestyle interventions competing, but drugs offer scalability.
●Bargaining Power of Buyers: Moderate, as unmet needs limit options, though insurers push pricing.
●Bargaining Power of Suppliers: Low-to-moderate, with broad supply chains supporting drug production.
●Competitive Rivalry: Intense, driven by first-mover advantages and pipeline races among Gilead and Merck.

Market Opportunities and Challenges
Opportunities
●Rising Prevalence: 342 million cases by 2030 create vast demand for NASH drugs.
●First Approval: Resmetirom’s success sets a precedent, accelerating market entry.
●Metabolic Focus: Overlap with obesity and diabetes opens cross-therapeutic potential.
●Investment Surge: High growth rates attract significant R&D funding.
Challenges
●Diagnostic Barriers: NASH’s silent progression delays treatment, limiting market reach.
●High Costs: Expensive drugs like resmetirom challenge affordability in emerging markets.
●Regulatory Hurdles: Rigorous efficacy proof slows pipeline approvals.
●Competition: Crowded pipeline increases rivalry, risking market saturation.
Table of Contents
Chapter 1 Executive Summary
Chapter 2 Abbreviation and Acronyms
Chapter 3 Preface
3.1 Research Scope
3.2 Research Sources
3.2.1 Data Sources
3.2.2 Assumptions
3.3 Research Method
Chapter 4 Market Landscape
4.1 Market Overview
4.2 Classification/Types
4.3 Application/End Users
Chapter 5 Market Trend Analysis
5.1 Introduction
5.2 Drivers
5.3 Restraints
5.4 Opportunities
5.5 Threats
Chapter 6 Industry Chain Analysis
6.1 Upstream/Suppliers Analysis
6.2 Non-Alcoholic Steatohepatitis Drug Analysis
6.2.1 Technology Analysis
6.2.2 Cost Analysis
6.2.3 Market Channel Analysis
6.3 Downstream Buyers/End Users
Chapter 7 Latest Market Dynamics
7.1 Latest News
7.2 Merger and Acquisition
7.3 Planned/Future Project
7.4 Policy Dynamics
Chapter 8 Historical and Forecast Non-Alcoholic Steatohepatitis Drug Market in North America (2020-2030)
8.1 Non-Alcoholic Steatohepatitis Drug Market Size
8.2 Non-Alcoholic Steatohepatitis Drug Market by End Use
8.3 Competition by Players/Suppliers
8.4 Non-Alcoholic Steatohepatitis Drug Market Size by Type
8.5 Key Countries Analysis
8.5.1 United States
8.5.2 Canada
8.5.3 Mexico
Chapter 9 Historical and Forecast Non-Alcoholic Steatohepatitis Drug Market in South America (2020-2030)
9.1 Non-Alcoholic Steatohepatitis Drug Market Size
9.2 Non-Alcoholic Steatohepatitis Drug Market by End Use
9.3 Competition by Players/Suppliers
9.4 Non-Alcoholic Steatohepatitis Drug Market Size by Type
9.5 Key Countries Analysis
9.5.1 Brazil
9.5.2 Argentina
9.5.3 Chile
9.5.4 Peru
Chapter 10 Historical and Forecast Non-Alcoholic Steatohepatitis Drug Market in Asia & Pacific (2020-2030)
10.1 Non-Alcoholic Steatohepatitis Drug Market Size
10.2 Non-Alcoholic Steatohepatitis Drug Market by End Use
10.3 Competition by Players/Suppliers
10.4 Non-Alcoholic Steatohepatitis Drug Market Size by Type
10.5 Key Countries Analysis
10.5.1 China
10.5.2 India
10.5.3 Japan
10.5.4 South Korea
10.5.5 Southest Asia
10.5.6 Australia
Chapter 11 Historical and Forecast Non-Alcoholic Steatohepatitis Drug Market in Europe (2020-2030)
11.1 Non-Alcoholic Steatohepatitis Drug Market Size
11.2 Non-Alcoholic Steatohepatitis Drug Market by End Use
11.3 Competition by Players/Suppliers
11.4 Non-Alcoholic Steatohepatitis Drug Market Size by Type
11.5 Key Countries Analysis
11.5.1 Germany
11.5.2 France
11.5.3 United Kingdom
11.5.4 Italy
11.5.5 Spain
11.5.6 Belgium
11.5.7 Netherlands
11.5.8 Austria
11.5.9 Poland
11.5.10 Russia
Chapter 12 Historical and Forecast Non-Alcoholic Steatohepatitis Drug Market in MEA (2020-2030)
12.1 Non-Alcoholic Steatohepatitis Drug Market Size
12.2 Non-Alcoholic Steatohepatitis Drug Market by End Use
12.3 Competition by Players/Suppliers
12.4 Non-Alcoholic Steatohepatitis Drug Market Size by Type
12.5 Key Countries Analysis
12.5.1 Egypt
12.5.2 Israel
12.5.3 South Africa
12.5.4 Gulf Cooperation Council Countries
12.5.5 Turkey
Chapter 13 Summary For Global Non-Alcoholic Steatohepatitis Drug Market (2020-2025)
13.1 Non-Alcoholic Steatohepatitis Drug Market Size
13.2 Non-Alcoholic Steatohepatitis Drug Market by End Use
13.3 Competition by Players/Suppliers
13.4 Non-Alcoholic Steatohepatitis Drug Market Size by Type
Chapter 14 Global Non-Alcoholic Steatohepatitis Drug Market Forecast (2025-2030)
14.1 Non-Alcoholic Steatohepatitis Drug Market Size Forecast
14.2 Non-Alcoholic Steatohepatitis Drug Application Forecast
14.3 Competition by Players/Suppliers
14.4 Non-Alcoholic Steatohepatitis Drug Type Forecast
Chapter 15 Analysis of Global Key Vendors
15.1 AstraZeneca PLC
15.1.1 Company Profile
15.1.2 Main Business and Non-alcoholic Steatohepatitis Drug Information
15.1.3 SWOT Analysis of AstraZeneca PLC
15.1.4 AstraZeneca PLC Non-alcoholic Steatohepatitis Drug Sales, Revenue, Price and Gross Margin (2020-2025)
15.2 Eli Lilly
15.2.1 Company Profile
15.2.2 Main Business and Non-alcoholic Steatohepatitis Drug Information
15.2.3 SWOT Analysis of Eli Lilly
15.2.4 Eli Lilly Non-alcoholic Steatohepatitis Drug Sales, Revenue, Price and Gross Margin (2020-2025)
15.3 Gilead Sciences
15.3.1 Company Profile
15.3.2 Main Business and Non-alcoholic Steatohepatitis Drug Information
15.3.3 SWOT Analysis of Gilead Sciences
15.3.4 Gilead Sciences Non-alcoholic Steatohepatitis Drug Sales, Revenue, Price and Gross Margin (2020-2025)
15.4 Merck & Co. Inc.
15.4.1 Company Profile
15.4.2 Main Business and Non-alcoholic Steatohepatitis Drug Information
15.4.3 SWOT Analysis of Merck & Co. Inc.
15.4.4 Merck & Co. Inc. Non-alcoholic Steatohepatitis Drug Sales, Revenue, Price and Gross Margin (2020-2025)
15.5 Novo Nordisk
15.5.1 Company Profile
15.5.2 Main Business and Non-alcoholic Steatohepatitis Drug Information
15.5.3 SWOT Analysis of Novo Nordisk
15.5.4 Novo Nordisk Non-alcoholic Steatohepatitis Drug Sales, Revenue, Price and Gross Margin (2020-2025)
15.6 Novartis AG
15.6.1 Company Profile
15.6.2 Main Business and Non-alcoholic Steatohepatitis Drug Information
15.6.3 SWOT Analysis of Novartis AG
15.6.4 Novartis AG Non-alcoholic Steatohepatitis Drug Sales, Revenue, Price and Gross Margin (2020-2025)
15.7 Pfizer Inc.
15.7.1 Company Profile
15.7.2 Main Business and Non-alcoholic Steatohepatitis Drug Information
15.7.3 SWOT Analysis of Pfizer Inc.
15.7.4 Pfizer Inc. Non-alcoholic Steatohepatitis Drug Sales, Revenue, Price and Gross Margin (2020-2025)
15.8 Roche Holding AG
15.8.1 Company Profile
15.8.2 Main Business and Non-alcoholic Steatohepatitis Drug Information
15.8.3 SWOT Analysis of Roche Holding AG
15.8.4 Roche Holding AG Non-alcoholic Steatohepatitis Drug Sales, Revenue, Price and Gross Margin (2020-2025)
15.9 Enanta Pharmaceuticals Inc.
15.9.1 Company Profile
15.9.2 Main Business and Non-alcoholic Steatohepatitis Drug Information
15.9.3 SWOT Analysis of Enanta Pharmaceuticals Inc.
15.9.4 Enanta Pharmaceuticals Inc. Non-alcoholic Steatohepatitis Drug Sales, Revenue, Price and Gross Margin (2020-2025)
15.10 Ionis Pharmceuticals Inc.
15.10.1 Company Profile
15.10.2 Main Business and Non-alcoholic Steatohepatitis Drug Information
15.10.3 SWOT Analysis of Ionis Pharmceuticals Inc.
15.10.4 Ionis Pharmceuticals Inc. Non-alcoholic Steatohepatitis Drug Sales, Revenue, Price and Gross Margin (2020-2025)
Please ask for sample pages for full companies list
Table Abbreviation And Acronyms
Table Research Scope Of Non-Alcoholic Steatohepatitis Drug Report
Table Data Sources Of Non-Alcoholic Steatohepatitis Drug Report
Table Major Assumptions Of Non-Alcoholic Steatohepatitis Drug Report
Table Non-Alcoholic Steatohepatitis Drug Classification
Table Non-Alcoholic Steatohepatitis Drug Applications
Table Drivers Of Non-Alcoholic Steatohepatitis Drug Market
Table Restraints Of Non-Alcoholic Steatohepatitis Drug Market
Table Opportunities Of Non-Alcoholic Steatohepatitis Drug Market
Table Threats Of Non-Alcoholic Steatohepatitis Drug Market
Table Raw Materials Suppliers
Table Different Production Methods Of Non-Alcoholic Steatohepatitis Drug
Table Cost Structure Analysis Of Non-Alcoholic Steatohepatitis Drug
Table Key End Users
Table Latest News Of Non-Alcoholic Steatohepatitis Drug Market
Table Merger And Acquisition
Table Planned/Future Project Of Non-Alcoholic Steatohepatitis Drug Market
Table Policy Of Non-Alcoholic Steatohepatitis Drug Market
Table 2020-2030 North America Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 North America Non-Alcoholic Steatohepatitis Drug Market Size By Application
Table 2020-2025 North America Non-Alcoholic Steatohepatitis Drug Key Players Revenue
Table 2020-2025 North America Non-Alcoholic Steatohepatitis Drug Key Players Market Share
Table 2020-2030 North America Non-Alcoholic Steatohepatitis Drug Market Size By Type
Table 2020-2030 United States Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 Canada Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 Mexico Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 South America Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 South America Non-Alcoholic Steatohepatitis Drug Market Size By Application
Table 2020-2025 South America Non-Alcoholic Steatohepatitis Drug Key Players Revenue
Table 2020-2025 South America Non-Alcoholic Steatohepatitis Drug Key Players Market Share
Table 2020-2030 South America Non-Alcoholic Steatohepatitis Drug Market Size By Type
Table 2020-2030 Brazil Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 Argentina Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 Chile Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 Peru Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 Asia & Pacific Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 Asia & Pacific Non-Alcoholic Steatohepatitis Drug Market Size By Application
Table 2020-2025 Asia & Pacific Non-Alcoholic Steatohepatitis Drug Key Players Revenue
Table 2020-2025 Asia & Pacific Non-Alcoholic Steatohepatitis Drug Key Players Market Share
Table 2020-2030 Asia & Pacific Non-Alcoholic Steatohepatitis Drug Market Size By Type
Table 2020-2030 China Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 India Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 Japan Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 South Korea Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 Southeast Asia Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 Australia Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 Europe Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 Europe Non-Alcoholic Steatohepatitis Drug Market Size By Application
Table 2020-2025 Europe Non-Alcoholic Steatohepatitis Drug Key Players Revenue
Table 2020-2025 Europe Non-Alcoholic Steatohepatitis Drug Key Players Market Share
Table 2020-2030 Europe Non-Alcoholic Steatohepatitis Drug Market Size By Type
Table 2020-2030 Germany Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 France Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 United Kingdom Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 Italy Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 Spain Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 Belgium Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 Netherlands Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 Austria Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 Poland Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 Russia Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 Mea Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 Mea Non-Alcoholic Steatohepatitis Drug Market Size By Application
Table 2020-2025 Mea Non-Alcoholic Steatohepatitis Drug Key Players Revenue
Table 2020-2025 Mea Non-Alcoholic Steatohepatitis Drug Key Players Market Share
Table 2020-2030 Mea Non-Alcoholic Steatohepatitis Drug Market Size By Type
Table 2020-2030 Egypt Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 Israel Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 South Africa Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 Gulf Cooperation Council Countries Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2030 Turkey Non-Alcoholic Steatohepatitis Drug Market Size
Table 2020-2025 Global Non-Alcoholic Steatohepatitis Drug Market Size By Region
Table 2020-2025 Global Non-Alcoholic Steatohepatitis Drug Market Size Share By Region
Table 2020-2025 Global Non-Alcoholic Steatohepatitis Drug Market Size By Application
Table 2020-2025 Global Non-Alcoholic Steatohepatitis Drug Market Share By Application
Table 2020-2025 Global Non-Alcoholic Steatohepatitis Drug Key Vendors Revenue
Table 2020-2025 Global Non-Alcoholic Steatohepatitis Drug Key Vendors Market Share
Table 2020-2025 Global Non-Alcoholic Steatohepatitis Drug Market Size By Type
Table 2020-2025 Global Non-Alcoholic Steatohepatitis Drug Market Share By Type
Table 2025-2030 Global Non-Alcoholic Steatohepatitis Drug Market Size By Region
Table 2025-2030 Global Non-Alcoholic Steatohepatitis Drug Market Size Share By Region
Table 2025-2030 Global Non-Alcoholic Steatohepatitis Drug Market Size By Application
Table 2025-2030 Global Non-Alcoholic Steatohepatitis Drug Market Share By Application
Table 2025-2030 Global Non-Alcoholic Steatohepatitis Drug Key Vendors Revenue
Table 2025-2030 Global Non-Alcoholic Steatohepatitis Drug Key Vendors Market Share
Table 2025-2030 Global Non-Alcoholic Steatohepatitis Drug Market Size By Type
Table 2025-2030 Non-Alcoholic Steatohepatitis Drug Global Market Share By Type

Figure Market Size Estimated Method
Figure Major Forecasting Factors
Figure Non-Alcoholic Steatohepatitis Drug Picture
Figure 2020-2030 North America Non-Alcoholic Steatohepatitis Drug Market Size And Cagr
Figure 2020-2030 South America Non-Alcoholic Steatohepatitis Drug Market Size And Cagr
Figure 2020-2030 Asia & Pacific Non-Alcoholic Steatohepatitis Drug Market Size And Cagr
Figure 2020-2030 Europe Non-Alcoholic Steatohepatitis Drug Market Size And Cagr
Figure 2020-2030 Mea Non-Alcoholic Steatohepatitis Drug Market Size And Cagr
Figure 2020-2025 Global Non-Alcoholic Steatohepatitis Drug Market Size And Growth Rate
Figure 2025-2030 Global Non-Alcoholic Steatohepatitis Drug Market Size And Growth Rate

Research Methodology

  • Market Estimated Methodology:

    Bottom-up & top-down approach, supply & demand approach are the most important method which is used by HDIN Research to estimate the market size.

1)Top-down & Bottom-up Approach

Top-down approach uses a general market size figure and determines the percentage that the objective market represents.

Bottom-up approach size the objective market by collecting the sub-segment information.

2)Supply & Demand Approach

Supply approach is based on assessments of the size of each competitor supplying the objective market.

Demand approach combine end-user data within a market to estimate the objective market size. It is sometimes referred to as bottom-up approach.

  • Forecasting Methodology
  • Numerous factors impacting the market trend are considered for forecast model:
  • New technology and application in the future;
  • New project planned/under contraction;
  • Global and regional underlying economic growth;
  • Threatens of substitute products;
  • Industry expert opinion;
  • Policy and Society implication.
  • Analysis Tools

1)PEST Analysis

PEST Analysis is a simple and widely used tool that helps our client analyze the Political, Economic, Socio-Cultural, and Technological changes in their business environment.

  • Benefits of a PEST analysis:
  • It helps you to spot business opportunities, and it gives you advanced warning of significant threats.
  • It reveals the direction of change within your business environment. This helps you shape what you’re doing, so that you work with change, rather than against it.
  • It helps you avoid starting projects that are likely to fail, for reasons beyond your control.
  • It can help you break free of unconscious assumptions when you enter a new country, region, or market; because it helps you develop an objective view of this new environment.

2)Porter’s Five Force Model Analysis

The Porter’s Five Force Model is a tool that can be used to analyze the opportunities and overall competitive advantage. The five forces that can assist in determining the competitive intensity and potential attractiveness within a specific area.

  • Threat of New Entrants: Profitable industries that yield high returns will attract new firms.
  • Threat of Substitutes: A substitute product uses a different technology to try to solve the same economic need.
  • Bargaining Power of Customers: the ability of customers to put the firm under pressure, which also affects the customer's sensitivity to price changes.
  • Bargaining Power of Suppliers: Suppliers of raw materials, components, labor, and services (such as expertise) to the firm can be a source of power over the firm when there are few substitutes.
  • Competitive Rivalry: For most industries the intensity of competitive rivalry is the major determinant of the competitiveness of the industry.

3)Value Chain Analysis

Value chain analysis is a tool to identify activities, within and around the firm and relating these activities to an assessment of competitive strength. Value chain can be analyzed by primary activities and supportive activities. Primary activities include: inbound logistics, operations, outbound logistics, marketing & sales, service. Support activities include: technology development, human resource management, management, finance, legal, planning.

4)SWOT Analysis

SWOT analysis is a tool used to evaluate a company's competitive position by identifying its strengths, weaknesses, opportunities and threats. The strengths and weakness is the inner factor; the opportunities and threats are the external factor. By analyzing the inner and external factors, the analysis can provide the detail information of the position of a player and the characteristics of the industry.

  • Strengths describe what the player excels at and separates it from the competition
  • Weaknesses stop the player from performing at its optimum level.
  • Opportunities refer to favorable external factors that the player can use to give it a competitive advantage.
  • Threats refer to factors that have the potential to harm the player.
  • Data Sources
Primary Sources Secondary Sources
Face to face/Phone Interviews with market participants, such as:
Manufactures;
Distributors;
End-users;
Experts.
Online Survey
Government/International Organization Data:
Annual Report/Presentation/Fact Book
Internet Source Information
Industry Association Data
Free/Purchased Database
Market Research Report
Book/Journal/News

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