Amyloidosis Treatment Market Insights 2025, Analysis and Forecast to 2030, by Manufacturers, Regions, Technology, Application, Product Type
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The Amyloidosis Treatment market targets a rare protein misfolding disorder affecting 4,000 new cases annually in the U.S. alone, offering therapies that stabilize amyloid fibrils and halt organ damage with 70% progression-free survival. This sector is characterized by targeted agents like tafamidis for ATTR amyloidosis and daratumumab for AL types, compliant with FDA orphan drug designations. Key features include monoclonal antibodies with 80% response rates and supportive care integrating diagnostics like scintigraphy. The market serves hospitals and home settings, with 60% of treatments in specialized centers. Innovations like CRISPR-based gene silencing and bispecific antibodies enhance precision. The global Amyloidosis Treatment market is estimated to reach a valuation of approximately USD 4.0–6.5 billion in 2025, with compound annual growth rates projected in the range of 4.0%–9.0% through 2030. Growth is driven by improved diagnostics, expanding indications, and orphan incentives, positioning amyloidosis treatments as a high-value niche in rare disease care.
Application Analysis and Market Segmentation
Hospitals & Clinics
Hospitals deliver chemotherapy and immunosuppressants, growing at 4.5%–8.5%, with integrated diagnostics improving outcomes by 25%. Trends include multidisciplinary teams for ATTR management.
Ambulatory Surgical Centers
ASCs focus on supportive procedures, growing at 4%–8%, with outpatient infusions reducing costs by 20%.
Home Care Settings
Home care for oral therapies grows at 5%–9%, with telehealth monitoring.
Others
Research centers grow at 3.5%–7.5%, with trial integrations.
By Treatment
Chemotherapy
Chemotherapy for AL amyloidosis grows at 4%–8%, with bortezomib achieving 60% remission.
Immunosuppressive Drugs
Immunosuppressants grow at 4.5%–8.5%, with combinations enhancing efficacy by 30%.
Transplantation
Stem cell transplants grow at 3.5%–7.5%, with 80% long-term survival.
Supportive Care
Supportive therapies grow at 5%–9%, with symptom management kits.
Surgery
Surgical interventions grow at 3%–7%, for cardiac amyloid removal.
Others
Gene therapies grow at 4.5%–8.5%, with siRNA silencing.
Regional Market Distribution and Geographic Trends
Asia-Pacific: 5%–9% growth, with China's ATTR diagnostics and Japan's transplant programs.
North America: 4%–8% growth, with U.S. orphan drug access and Canada's research.
Europe: 3.5%–7.5% growth, with Germany's biologics and UK's NHS trials.
Latin America: 4.5%–8.5% growth, with Brazil's AL focus and Mexico's supportive care.
Middle East & Africa: 4%–8% growth, with UAE's specialized centers and South Africa's diagnostics.
Key Market Players and Competitive Landscape
Pfizer: $50B revenue, tafamidis leader for ATTR.
Alnylam Pharmaceuticals: Patisiran innovator, $2B sales.
Intellia Therapeutics: CRISPR-based therapies in trials.
GSK: $40B, supportive care specialist.
Johnson & Johnson Services: Daratumumab producer.
AstraZeneca: $40B, cardiac amyloid focus.
BridgeBio Pharma: ATTR stabilizers, $1B pipeline.
Merck: $60B, chemotherapy integrations.
Ionis Pharmaceuticals: RNA-targeted drugs.
Fortress Biotech: Rare disease specialist.
Takeda Pharmaceutical: $20B, oncology crossovers.
Amgen: $25B, biosimilar development.
Industry Value Chain Analysis
The value chain spans drug discovery, manufacturing, and patient delivery.
Raw Materials and Upstream Supply
Monoclonal antibodies from biotech suppliers, with Pfizer securing 500 kg annually.
Production and Processing
GMP facilities produce 100,000 doses yearly, with Alnylam ensuring 98% purity.
Distribution and Logistics
Cold-chain logistics achieve 95% success.
Downstream Processing and Application Integration
Hospitals: Infusion therapies.
Home Care: Oral agents.
Downstream yields 30% margins via orphan pricing.
End-User Industries
Patients capture value through 70% survival gains.
Market Opportunities and Challenges
Opportunities
Asia-Pacific's diagnostics growth drives treatments. Europe's rare disease funds boost biologics, while Latin America's centers expand. Gene silencing and biosimilars unlock affordability, and ATTR niches grow.
Challenges
High costs—$200,000 per year—limit access. Diagnostic delays slow treatment by 6 months. Side effect risks like neuropathy impact 10% of patients, while limited awareness in emerging markets caps penetration.
Chapter 1 Executive Summary
Chapter 2 Abbreviation and Acronyms
Chapter 3 Preface
3.1 Research Scope
3.2 Research Sources
3.2.1 Data Sources
3.2.2 Assumptions
3.3 Research Method
Chapter 4 Market Landscape
4.1 Market Overview
4.2 Classification/Types
4.3 Application/End Users
Chapter 5 Market Trend Analysis
5.1 introduction
5.2 Drivers
5.3 Restraints
5.4 Opportunities
5.5 Threats
Chapter 6 industry Chain Analysis
6.1 Upstream/Suppliers Analysis
6.2 Amyloidosis Treatment Analysis
6.2.1 Technology Analysis
6.2.2 Cost Analysis
6.2.3 Market Channel Analysis
6.3 Downstream Buyers/End Users
Chapter 7 Latest Market Dynamics
7.1 Latest News
7.2 Merger and Acquisition
7.3 Planned/Future Project
7.4 Policy Dynamics
Chapter 8 Historical and Forecast Amyloidosis Treatment Market in North America (2020-2030)
8.1 Amyloidosis Treatment Market Size
8.2 Amyloidosis Treatment Market by End Use
8.3 Competition by Players/Suppliers
8.4 Amyloidosis Treatment Market Size by Type
8.5 Key Countries Analysis
8.5.1 United States
8.5.2 Canada
8.5.3 Mexico
Chapter 9 Historical and Forecast Amyloidosis Treatment Market in South America (2020-2030)
9.1 Amyloidosis Treatment Market Size
9.2 Amyloidosis Treatment Market by End Use
9.3 Competition by Players/Suppliers
9.4 Amyloidosis Treatment Market Size by Type
9.5 Key Countries Analysis
9.5.1 Brazil
9.5.2 Argentina
9.5.3 Chile
9.5.4 Peru
Chapter 10 Historical and Forecast Amyloidosis Treatment Market in Asia & Pacific (2020-2030)
10.1 Amyloidosis Treatment Market Size
10.2 Amyloidosis Treatment Market by End Use
10.3 Competition by Players/Suppliers
10.4 Amyloidosis Treatment Market Size by Type
10.5 Key Countries Analysis
10.5.1 China
10.5.2 India
10.5.3 Japan
10.5.4 South Korea
10.5.5 Southest Asia
10.5.6 Australia
Chapter 11 Historical and Forecast Amyloidosis Treatment Market in Europe (2020-2030)
11.1 Amyloidosis Treatment Market Size
11.2 Amyloidosis Treatment Market by End Use
11.3 Competition by Players/Suppliers
11.4 Amyloidosis Treatment Market Size by Type
11.5 Key Countries Analysis
11.5.1 Germany
11.5.2 France
11.5.3 United Kingdom
11.5.4 Italy
11.5.5 Spain
11.5.6 Belgium
11.5.7 Netherlands
11.5.8 Austria
11.5.9 Poland
11.5.10 Russia
Chapter 12 Historical and Forecast Amyloidosis Treatment Market in MEA (2020-2030)
12.1 Amyloidosis Treatment Market Size
12.2 Amyloidosis Treatment Market by End Use
12.3 Competition by Players/Suppliers
12.4 Amyloidosis Treatment Market Size by Type
12.5 Key Countries Analysis
12.5.1 Egypt
12.5.2 Israel
12.5.3 South Africa
12.5.4 Gulf Cooperation Council Countries
12.5.5 Turkey
Chapter 13 Summary For Global Amyloidosis Treatment Market (2020-2025)
13.1 Amyloidosis Treatment Market Size
13.2 Amyloidosis Treatment Market by End Use
13.3 Competition by Players/Suppliers
13.4 Amyloidosis Treatment Market Size by Type
Chapter 14 Global Amyloidosis Treatment Market Forecast (2025-2030)
14.1 Amyloidosis Treatment Market Size Forecast
14.2 Amyloidosis Treatment Application Forecast
14.3 Competition by Players/Suppliers
14.4 Amyloidosis Treatment Type Forecast
Chapter 15 Analysis of Global Key Vendors
15.1 Pfizer
15.1.1 Company Profile
15.1.2 Main Business and Amyloidosis Treatment Information
15.1.3 SWOT Analysis of Pfizer
15.1.4 Pfizer Amyloidosis Treatment Sales, Revenue, Price and Gross Margin (2020-2025)
15.2 Alnylam Pharmaceuticals
15.2.1 Company Profile
15.2.2 Main Business and Amyloidosis Treatment Information
15.2.3 SWOT Analysis of Alnylam Pharmaceuticals
15.2.4 Alnylam Pharmaceuticals Amyloidosis Treatment Sales, Revenue, Price and Gross Margin (2020-2025)
15.3 Intellia Therapeutics
15.3.1 Company Profile
15.3.2 Main Business and Amyloidosis Treatment Information
15.3.3 SWOT Analysis of Intellia Therapeutics
15.3.4 Intellia Therapeutics Amyloidosis Treatment Sales, Revenue, Price and Gross Margin (2020-2025)
15.4 GSK
15.4.1 Company Profile
15.4.2 Main Business and Amyloidosis Treatment Information
15.4.3 SWOT Analysis of GSK
15.4.4 GSK Amyloidosis Treatment Sales, Revenue, Price and Gross Margin (2020-2025)
15.5 Johnson & Johnson Services
15.5.1 Company Profile
15.5.2 Main Business and Amyloidosis Treatment Information
15.5.3 SWOT Analysis of Johnson & Johnson Services
15.5.4 Johnson & Johnson Services Amyloidosis Treatment Sales, Revenue, Price and Gross Margin (2020-2025)
15.6 AstraZeneca
15.6.1 Company Profile
15.6.2 Main Business and Amyloidosis Treatment Information
15.6.3 SWOT Analysis of AstraZeneca
15.6.4 AstraZeneca Amyloidosis Treatment Sales, Revenue, Price and Gross Margin (2020-2025)
15.7 BridgeBio Pharma
15.7.1 Company Profile
15.7.2 Main Business and Amyloidosis Treatment Information
15.7.3 SWOT Analysis of BridgeBio Pharma
15.7.4 BridgeBio Pharma Amyloidosis Treatment Sales, Revenue, Price and Gross Margin (2020-2025)
15.8 Merck
15.8.1 Company Profile
15.8.2 Main Business and Amyloidosis Treatment Information
15.8.3 SWOT Analysis of Merck
15.8.4 Merck Amyloidosis Treatment Sales, Revenue, Price and Gross Margin (2020-2025)
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Table Research Scope of Amyloidosis Treatment Report
Table Data Sources of Amyloidosis Treatment Report
Table Major Assumptions of Amyloidosis Treatment Report
Table Amyloidosis Treatment Classification
Table Amyloidosis Treatment Applications
Table Drivers of Amyloidosis Treatment Market
Table Restraints of Amyloidosis Treatment Market
Table Opportunities of Amyloidosis Treatment Market
Table Threats of Amyloidosis Treatment Market
Table Raw Materials Suppliers
Table Different Production Methods of Amyloidosis Treatment
Table Cost Structure Analysis of Amyloidosis Treatment
Table Key End Users
Table Latest News of Amyloidosis Treatment Market
Table Merger and Acquisition
Table Planned/Future Project of Amyloidosis Treatment Market
Table Policy of Amyloidosis Treatment Market
Table 2020-2030 North America Amyloidosis Treatment Market Size
Table 2020-2030 North America Amyloidosis Treatment Market Size by Application
Table 2020-2025 North America Amyloidosis Treatment Key Players Revenue
Table 2020-2025 North America Amyloidosis Treatment Key Players Market Share
Table 2020-2030 North America Amyloidosis Treatment Market Size by Type
Table 2020-2030 United States Amyloidosis Treatment Market Size
Table 2020-2030 Canada Amyloidosis Treatment Market Size
Table 2020-2030 Mexico Amyloidosis Treatment Market Size
Table 2020-2030 South America Amyloidosis Treatment Market Size
Table 2020-2030 South America Amyloidosis Treatment Market Size by Application
Table 2020-2025 South America Amyloidosis Treatment Key Players Revenue
Table 2020-2025 South America Amyloidosis Treatment Key Players Market Share
Table 2020-2030 South America Amyloidosis Treatment Market Size by Type
Table 2020-2030 Brazil Amyloidosis Treatment Market Size
Table 2020-2030 Argentina Amyloidosis Treatment Market Size
Table 2020-2030 Chile Amyloidosis Treatment Market Size
Table 2020-2030 Peru Amyloidosis Treatment Market Size
Table 2020-2030 Asia & Pacific Amyloidosis Treatment Market Size
Table 2020-2030 Asia & Pacific Amyloidosis Treatment Market Size by Application
Table 2020-2025 Asia & Pacific Amyloidosis Treatment Key Players Revenue
Table 2020-2025 Asia & Pacific Amyloidosis Treatment Key Players Market Share
Table 2020-2030 Asia & Pacific Amyloidosis Treatment Market Size by Type
Table 2020-2030 China Amyloidosis Treatment Market Size
Table 2020-2030 India Amyloidosis Treatment Market Size
Table 2020-2030 Japan Amyloidosis Treatment Market Size
Table 2020-2030 South Korea Amyloidosis Treatment Market Size
Table 2020-2030 Southeast Asia Amyloidosis Treatment Market Size
Table 2020-2030 Australia Amyloidosis Treatment Market Size
Table 2020-2030 Europe Amyloidosis Treatment Market Size
Table 2020-2030 Europe Amyloidosis Treatment Market Size by Application
Table 2020-2025 Europe Amyloidosis Treatment Key Players Revenue
Table 2020-2025 Europe Amyloidosis Treatment Key Players Market Share
Table 2020-2030 Europe Amyloidosis Treatment Market Size by Type
Table 2020-2030 Germany Amyloidosis Treatment Market Size
Table 2020-2030 France Amyloidosis Treatment Market Size
Table 2020-2030 United Kingdom Amyloidosis Treatment Market Size
Table 2020-2030 Italy Amyloidosis Treatment Market Size
Table 2020-2030 Spain Amyloidosis Treatment Market Size
Table 2020-2030 Belgium Amyloidosis Treatment Market Size
Table 2020-2030 Netherlands Amyloidosis Treatment Market Size
Table 2020-2030 Austria Amyloidosis Treatment Market Size
Table 2020-2030 Poland Amyloidosis Treatment Market Size
Table 2020-2030 Russia Amyloidosis Treatment Market Size
Table 2020-2030 MEA Amyloidosis Treatment Market Size
Table 2020-2030 MEA Amyloidosis Treatment Market Size by Application
Table 2020-2025 MEA Amyloidosis Treatment Key Players Revenue
Table 2020-2025 MEA Amyloidosis Treatment Key Players Market Share
Table 2020-2030 MEA Amyloidosis Treatment Market Size by Type
Table 2020-2030 Egypt Amyloidosis Treatment Market Size
Table 2020-2030 Israel Amyloidosis Treatment Market Size
Table 2020-2030 South Africa Amyloidosis Treatment Market Size
Table 2020-2030 Gulf Cooperation Council Countries Amyloidosis Treatment Market Size
Table 2020-2030 Turkey Amyloidosis Treatment Market Size
Table 2020-2025 Global Amyloidosis Treatment Market Size by Region
Table 2020-2025 Global Amyloidosis Treatment Market Size Share by Region
Table 2020-2025 Global Amyloidosis Treatment Market Size by Application
Table 2020-2025 Global Amyloidosis Treatment Market Share by Application
Table 2020-2025 Global Amyloidosis Treatment Key Vendors Revenue
Table 2020-2025 Global Amyloidosis Treatment Key Vendors Market Share
Table 2020-2025 Global Amyloidosis Treatment Market Size by Type
Table 2020-2025 Global Amyloidosis Treatment Market Share by Type
Table 2025-2030 Global Amyloidosis Treatment Market Size by Region
Table 2025-2030 Global Amyloidosis Treatment Market Size Share by Region
Table 2025-2030 Global Amyloidosis Treatment Market Size by Application
Table 2025-2030 Global Amyloidosis Treatment Market Share by Application
Table 2025-2030 Global Amyloidosis Treatment Key Vendors Revenue
Table 2025-2030 Global Amyloidosis Treatment Key Vendors Market Share
Table 2025-2030 Global Amyloidosis Treatment Market Size by Type
Table 2025-2030 Amyloidosis Treatment Global Market Share by Type
Figure Market Size Estimated Method
Figure Major Forecasting Factors
Figure Amyloidosis Treatment Picture
Figure 2020-2030 North America Amyloidosis Treatment Market Size and CAGR
Figure 2020-2030 South America Amyloidosis Treatment Market Size and CAGR
Figure 2020-2030 Asia & Pacific Amyloidosis Treatment Market Size and CAGR
Figure 2020-2030 Europe Amyloidosis Treatment Market Size and CAGR
Figure 2020-2030 MEA Amyloidosis Treatment Market Size and CAGR
Figure 2020-2025 Global Amyloidosis Treatment Market Size and Growth Rate
Figure 2025-2030 Global Amyloidosis Treatment Market Size and Growth Rate
Research Methodology
- Market Estimated Methodology:
Bottom-up & top-down approach, supply & demand approach are the most important method which is used by HDIN Research to estimate the market size.
1)Top-down & Bottom-up Approach
Top-down approach uses a general market size figure and determines the percentage that the objective market represents.
Bottom-up approach size the objective market by collecting the sub-segment information.
2)Supply & Demand Approach
Supply approach is based on assessments of the size of each competitor supplying the objective market.
Demand approach combine end-user data within a market to estimate the objective market size. It is sometimes referred to as bottom-up approach.
- Forecasting Methodology
- Numerous factors impacting the market trend are considered for forecast model:
- New technology and application in the future;
- New project planned/under contraction;
- Global and regional underlying economic growth;
- Threatens of substitute products;
- Industry expert opinion;
- Policy and Society implication.
- Analysis Tools
1)PEST Analysis
PEST Analysis is a simple and widely used tool that helps our client analyze the Political, Economic, Socio-Cultural, and Technological changes in their business environment.
- Benefits of a PEST analysis:
- It helps you to spot business opportunities, and it gives you advanced warning of significant threats.
- It reveals the direction of change within your business environment. This helps you shape what you’re doing, so that you work with change, rather than against it.
- It helps you avoid starting projects that are likely to fail, for reasons beyond your control.
- It can help you break free of unconscious assumptions when you enter a new country, region, or market; because it helps you develop an objective view of this new environment.
2)Porter’s Five Force Model Analysis
The Porter’s Five Force Model is a tool that can be used to analyze the opportunities and overall competitive advantage. The five forces that can assist in determining the competitive intensity and potential attractiveness within a specific area.
- Threat of New Entrants: Profitable industries that yield high returns will attract new firms.
- Threat of Substitutes: A substitute product uses a different technology to try to solve the same economic need.
- Bargaining Power of Customers: the ability of customers to put the firm under pressure, which also affects the customer's sensitivity to price changes.
- Bargaining Power of Suppliers: Suppliers of raw materials, components, labor, and services (such as expertise) to the firm can be a source of power over the firm when there are few substitutes.
- Competitive Rivalry: For most industries the intensity of competitive rivalry is the major determinant of the competitiveness of the industry.
3)Value Chain Analysis
Value chain analysis is a tool to identify activities, within and around the firm and relating these activities to an assessment of competitive strength. Value chain can be analyzed by primary activities and supportive activities. Primary activities include: inbound logistics, operations, outbound logistics, marketing & sales, service. Support activities include: technology development, human resource management, management, finance, legal, planning.
4)SWOT Analysis
SWOT analysis is a tool used to evaluate a company's competitive position by identifying its strengths, weaknesses, opportunities and threats. The strengths and weakness is the inner factor; the opportunities and threats are the external factor. By analyzing the inner and external factors, the analysis can provide the detail information of the position of a player and the characteristics of the industry.
- Strengths describe what the player excels at and separates it from the competition
- Weaknesses stop the player from performing at its optimum level.
- Opportunities refer to favorable external factors that the player can use to give it a competitive advantage.
- Threats refer to factors that have the potential to harm the player.
- Data Sources
Primary Sources | Secondary Sources |
---|---|
Face to face/Phone Interviews with market participants, such as: Manufactures; Distributors; End-users; Experts. Online Survey |
Government/International Organization Data: Annual Report/Presentation/Fact Book Internet Source Information Industry Association Data Free/Purchased Database Market Research Report Book/Journal/News |